ENANTIOSELECTIVE MULTICATALYSED TANDEM REACTIONS | by Hélène Pellissier | ‎ Royal Society of Chemistry | ‎ English | ‎ GLD Edition

Product description Review Select Guide Rating From the Back Cover Chiral molecules are needed for the production of many pharmaceuticals and materials, and catalytic asymmetric synthesis provides a method for the preparation of such chiral products. For the synthesis of complex molecules, such as natural products and biologically active compounds, more than one catalytic reaction may be necessary and tandem catalysis refers to the combination of catalytic reactions into one synthesis. By combing catalysts it enables a more efficient, economical and selective one pot approach for complex molecule synthesis which could not be achieved through single specific catalytic systems. The challenge is finding the right catalyst which is compatible with other catalysts but also tolerates reagents, solvent and intermediates generated during the course of the reaction.Enantioselective Multicatalysed Tandem Reactions provides an overview of recent developments in the area. The first part of the book covers asymmetric tandem reactions catalysed by multiple catalysts from the same discipline (organocatalysts, two metal and multienzyme-catalysed reactions). The second part looks at tandem reactions catalysed by multiple catalysts from different disciplines including reactions catalysed by a combination of metals and organocatalysts, reactions catalysed by a combination of metals and enzymes, and finally reactions catalysed by a combination of organocatalysts and enzymes.The book will appeal to researchers and professionals in academic and industrial laboratories interested in catalysis, biocatalysis and organic synthesis of chiral compounds. About the Author Hélène Pellissier is a Researcher at the Centre National de la Recherche Scientifique (CNRS), where she focuses in organic synthesis. Excerpt. © Reprinted by permission. All rights reserved. Enantioselective Multicatalysed Tandem ReactionsBy Hélène PellissierThe Royal Society of ChemistryCopyright © 2014 Hélène PellissierAll rights reserved.ISBN: 978-1-84973-988-7ContentsAbbreviations, xvii, Section I Asymmetric Tandem Reactions Catalysed by Multiple Catalysts from the Same Discipline, Chapter 1 Introduction, 3, Chapter 2 Reactions Catalysed by Multiple Organocatalysts, 5, Chapter 3 Reactions Catalysed by Two Metals, 46, Chapter 4 Multienzyme-Catalysed Reactions, 60, Chapter 5 Conclusions, 85, Section II Asymmetric Tandem Reactions Catalysed by Multiple Catalysts from Different Disciplines, Chapter 6 Introduction, 89, Chapter 7 Reactions Catalysed by a Combination of Metals and Organocatalysts, 91, Chapter 8 Reactions Catalysed by a Combination of Metals and Enzymes, 162, Chapter 9 Reactions Catalysed by a Combination of Organocatalysts and Enzymes, 217, Chapter 10 Conclusions, 223, General Conclusion, 224, Subject Index, 226, CHAPTER 1IntroductionThe first section of the book illustrates how much asymmetric multicatalysis based on the use of catalysts belonging to the same discipline has contributed to the development of various types of powerful enantioselective tandem reactions. It collects all the major progress in the field of enantioselective tandem reactions promoted by multiple (two or three) organocatalysts, two metal catalysts, or two or more biocatalysts. It demonstrates the power of these remarkable one-pot processes of two or more bond-forming reactions, occurring with minimum workup or change in conditions in which the subsequent transformation takes place at the functionalities obtained in the former transformation, following the same principles that are found in biosynthesis in nature. The first section of the book is subdivided into five chapters, dealing successively after this introduction (Chapter 1) with reactions catalysed by multiple organocatalysts (Chapter 2), reactions catalysed by two metals (Chapter 3), and multienzyme-catalysed reactions (Chapter 4) followed by conclusions (Chapter 5). The two catalysts can interact in a cooperative, relay or sequential manner; these three types of catalysis will be treated successively in chapters 2 and 3. In cooperative catalysis, both the two catalysts are present at the onset of the reaction, and share the same catalytic cycle, activating two different functional groups cooperatively to achieve the bond-formation steps. On the other hand, in relay or sequential catalysis, the substrate first reacts with one catalyst to give an intermediate through a first catalytic cycle. Then, this former intermediate reacts with the second catalyst to provide, through a second catalytic cycle, the final product or an intermediate for subsequent transformations. The difference between relay and sequential catalysis consists of the presence or not of the two catalysts at the onset of the reaction. Thus, relay as well as sequential catalysis involves a set of reactions independently catalysed by two catalysts in a consecutive manner but, while in relay catalysis the two compatible catalysts are both present from onset, i