ASYMMETRIC DOMINO REACTIONS | by Hélène Pellissier | ‎ SP RSC PUBLISHING | ‎ English

Product description Review Select Guide Rating From the Back Cover This book covers the latest developments in asymmetric domino reactions, focussing on those published in the last 6 years. These fascinating reactions have rapidly become one of the most current fields in organic chemistry, since they allow reaching easily high molecular complexity in an economically favourable way with advantages of savings in solvent, time, energy, and costs. Unsurprisingly, the high levels of efficiency and enantioselectivity generally reached in these reactions have been exploited for the production of a wide number of complex chiral molecules with dense stereochemistry and functionality, which are motifs present in biologically active compounds and natural products. The book is divided into three principal sections, dealing successively with asymmetric domino reactions based on the use of chiral auxiliaries, asymmetric domino reactions based on the use of chiral metal catalysts, and asymmetric domino reactions based on the use of chiral organocatalysts, covering the literature since the beginning of 2006. About the Author Hélène Pellissier was born in Gap, France. She carried out her PhD under the supervision of Dr G. Gil in Marseille and then entered the Centre National de la Recherche Scientifique in 1988. After a postdoctoral position in Professor K. P. C. Vollhardt's group at Berkeley, she joined the group of Professor M. Santelli in Marseille in 1992. Here she focused on the chemistry of BISTRO and its large application in organic synthesis.Hélène Pellissier was born in Gap, France. She carried out her PhD under the supervision of Dr G. Gil in Marseille and then entered the Centre National de la Recherche Scientifique in 1988. After a postdoctoral position in Professor K. P. C. Vollhardt's group at Berkeley, she joined the group of Professor M. Santelli in Marseille in 1992. Here she focused on the chemistry of BISTRO and its large application in organic synthesis. Excerpt. © Reprinted by permission. All rights reserved. Asymmetric Domino ReactionsBy Hélène PellissierThe Royal Society of ChemistryCopyright © 2013 The Royal Society of ChemistryAll rights reserved.ISBN: 978-1-84973-651-0ContentsAbbreviations, xiii, Chapter 1 Asymmetric Domino Reactions Based on the Use of Chiral Substrates, 1, Chapter 2 Asymmetric Domino Reactions Based on the Use of Chiral Metal Catalysts, 150, Chapter 3 Asymmetric Domino Reactions Based on the Use of Chiral Organocatalysts, 251, General Conclusion, 468, Subject Index, 470, CHAPTER 1Asymmetric Domino Reactions Based on the Use of Chiral Substrates1.1 IntroductionOf the methods available for preparing chiral compounds, asymmetric synthesis from chiral substrates still attracts a lot of attention. Indeed, it remains the method most commonly employed in total synthesis of optically active compounds, playing an important role in medicine and materials as well as natural products, in spite of the explosive growth of organocatalysis in the last decade, and its application in the synthesis of a number of chiral products. The last six years have witnessed an explosive growth in the field of asymmetric domino reactions starting from chiral substrates and auxiliaries, with an impressive number of novel methodologies and applications in total synthesis. The goal of this chapter is to cover the recent efforts of the chemical community in the development of novel domino reactions of chiral substrates, including chiral auxiliaries and their wide applications in total synthesis, published since the beginning of 2006. This field was most recently reviewed in 2006 by Tietze in a book, and by this author in a review, covering the literature until the beginning of 2006. The domino reactions are catalogued on the basis of the reaction types involved in the first synthetic step(s). They have been selected according to Tietze's definition, qualifying a domino reaction as a reaction involving two or more bond-forming transformations which take place under the same reaction conditions, without adding additional reagents and catalysts, and in which the subsequent reactions are a consequence of the functionality formed by bond formation or fragmentation in the previous step. In order to facilitate presentation, the chapter is divided into two principal sections, dealing successively with one- and two-component domino reactions, and multicomponent domino reactions. The first section, describing the asymmetric one- and two-component domino reactions, is subdivided into eight sections which successively deal with domino reactions with an anionic primary step, domino reactions based on cationic sequences, domino reactions initiated by a pericyclic primary step, domino reactions based on carbene sequences, palladium-catalysed domino reactions, ruthenium-catalysed domino reactions, gold-catalysed domino reactions, and finally miscellaneous domino reactions. The second section of the chapter, describing the asymmet