Carbohydrate Chemistry Volume 15, Part Ii: Volume 15II (Specialist Periodical Reports - Carbohydrate Chemistry)

Product description From the Back Cover Carbohydrate Chemistry provides review coverage of all publications relevant to the chemistry of monosaccharides and oligosaccharides in a given year. The amount of research in this field appearing in the organic chemical literature is increasing because of the enhanced importance of the subject, especially in areas of medicinal chemistry and biology. In no part of the field is this more apparent than in the synthesis of oligosaccharides required by scientists working in glycobiology. Clycomedicinal chemistry and its reliance on carbohydrate synthesis is now very well established, for example, by the preparation of specific carbohydrate- based antigens, especially cancer-specific oligosaccharides and glycoconjugates. Coverage of topics such as nucleosides, amino-sugars, alditols and cyclitols also covers much research of relevance to biological and medicinal chemistry. Each volume of the series brings together references to all published work in given areas of the subject and serves as a comprehensive database for the active research chemist Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis. Excerpt. © Reprinted by permission. All rights reserved. Carbohydrate Chemistry Volume 15Mono-, Di-, and Tri-saccharides and Their DerivativesBy N. R. WilliamsThe Royal Society of ChemistryCopyright © 1983 The Royal Society of ChemistryAll rights reserved.ISBN: 978-0-85186-152-4Contents1 Introduction, 3, 2 Free Sugars, 5, 3 Glycosides, 18, 4 Ethers and Anhydro-sugars, 50, 5 Acetals, 60, 6 Esters, 67, 7 Halogeno-sugars, 84, 8 Amino-sugars, 91, 9 Miscellaneous Nitrogen Derivatives, 106, 10 Thio- and Seleno-sugars, 117, 11 Deoxy-sugars, 124, 12 Unsaturated Derivatives, 129, 13 Branched-chain Sugars, 139, 14 Aldosuloses, Dialdoses, and Diuloses, 146, 15 Sugar Acids and Lactones, 150, 16 Inorganic Derivatives, 160, 17 Alditols and Cyclitols, 166, 18 Antibiotics, 176, 19 Nucleosides, 198, 20 N.m.r. Spectroscopy and Conformational Features, 222, 21 Other Physical Methods, 231, 22 Separatory and Analytical Methods Chromatographic Methods, 243, 23 Synthesis of Enantiomerically Pure Non-carbohydrate, 251, Author Index, 263, CHAPTER 1IntroductionAlthough the two parts of this report are now being published separately , the general format and coverage of this section, covering the organic chemistry of mono-, di-, and tri-saccharides, has not been changed. It might be helpful to point out firstly that a hard and fast division has not been drawn between trisaccharides and higher oligosaccharides, particularly in the chapters dealing with glycosides and antibiotics, and secondly that the coverage on glycosides, antibiotics, nucleosides and related compounds containing carbohydrate units is selective for those papers where there is judged to be some specific carbohydrate interest besides any for the aglycone components; in the fringe areas, we hope this principle is acceptable in the interests of keeping the report within reasonable, economic limits.The trends in research endeavour noted in recent reports have been continued, and the extensive sections on glycoside synthesis, antibiotics and nucleosides reflect the major interest in these areas. The synthesis of tri- and higher oligosaccharides is fast becoming a routine procedure for providing substrates of immunochemical interest. New antibiotic materials continue to be discovered consisting mainly or entirely of carbohydrate components in complex structures, and a ever widening variety of nucleoside analogues have been reported. These areas pose problems in classification, and we hope the distinctions that have been drawn between nucleosides on the one hand and miscellaneous nitrogen compounds on the other have not been too arbitrary for general acceptance. Another growth area has been the application of carbohydrates as chiral templates for the synthesis of a wide range of naturally occurring chiral compounds. Chapters 20 and 21 reflect the fruitful application of both routine and newer developments in spectroscopic techniques for the analysis of carbohydrate compounds and illustrate how much can be learned about relatively complex materials without actually doing any chemistry on them.Recommendations for the nomenclature of unsaturated and branched-chain sugars, and of conformations of five and six-membered rings have been published during the year.CHAPTER 2Free SugarsThe main pathways of reaction of primary free radicals in carbohydrates have been reviewed. A review on the use of sugars in fermentation and for preparation of sweeteners, plasti