Organometallic Chemistry: Volume 40 (Specialist Periodical Reports - Organometallic Chemistry)

Product description From the Inside Flap Keeping up with the literature in a fast moving science discipline can be difficult so finding a distilled view of the latest progress in an area is invaluable. In this celebratory volume, the editors have approached leading researchers to review the area of organometallic chemistry spanning the years. This interdisciplinary field has the potential to provide answers to problems and challenges faced in catalysis, synthetic organic chemistry and unusal reactivity and the development of new materials. Providing a timely addition to the literature, this volume will reflect current interests as well as look at how these have developed over the years and even explore future applications. From the Back Cover Keeping up with the literature in a fast moving science discipline can be difficult so finding a distilled view of the latest progress in an area is invaluable. In this celebratory volume, the editors have approached leading researchers to review the area of organometallic chemistry spanning the years. This interdisciplinary field has the potential to provide answers to problems and challenges faced in catalysis, synthetic organic chemistry and unusal reactivity and the development of new materials. Providing a timely addition to the literature, this volume will reflect current interests as well as look at how these have developed over the years and even explore future applications. Excerpt. © Reprinted by permission. All rights reserved. Organometallic Chemistry Volume 40By Ian Fairlamb, Jason LynamThe Royal Society of ChemistryCopyright © 2016 The Royal Society of ChemistryAll rights reserved.ISBN: 978-1-84973-984-9ContentsPreface Ian J. S. Fairlamb and Jason M. Lynam, v, Overcoming synthetic challenges in target synthesis using SmI2: recent advances Xavier Just-Baringo, Irem Yalavac and David Procter, 1, Pd(0) nanoparticles (NPs) as catalysts in cross-coupling reactions and the homogeneous vs. heterogeneous debate Eoin Ó Muimhneacháin and Gerard P. McGlacken, 33, Recent developments in selective C–H functionalisation Christopher G. Frost, Patricia Marce and Po Man Liu, 54, Recent advances in the chemistry of metal–metal quadruple bonds Nathan J. Patmore, 88, N-Heterocyclic carbenes; partakers not just spectators Benjamin R. M. Lake, Michael R. Chapman and Charlotte E. Willans, 107, Carbon monoxide-releasing molecules: therapeutic molecules with a wide variety of medical applications Jonathan S. Ward, 140, Alkali/coinage metals – organolithium, organocuprate chemistry Andrew J. Peel and Andrew E. H. Wheatley, 177, CHAPTER 1Overcoming synthetic challenges in target synthesis using SmI2: recent advancesXavier Just-Baringo, Irem Yalavac and David Procter *DOI: 10.1039/9781782623960-00001Samarium (II) iodide (SmI2, Kagan's reagent) is one of the most important reducing agents in organic synthesis. Its unique reactivity and selectivity makes it ideal for mediating key steps in target syntheses often providing outcomes that simply cannot be matched by other reagents. In this review we present selected examples of the application of SmI2 in target-oriented synthesis during the last four years and describe the enabling role the reagent has played in the construction of natural products, unnatural bioactive compounds, and organic materials.1 IntroductionSamarium (II) iodide (SmI2, Kagan's reagent) has played an increasingly important role in synthetic organic chemistry since its introduction by Kagan in 1977. The possibility of fine-tuning its reactivity by the addition of additives and its impressive chemoselectivity, arguably make it the most versatile electron transfer (ET) reagent available to the organic chemist. SmI2 is a user-friendly reagent that provides mild reaction conditions and grants access to a large number of different transformations, making it a broadly useful reagent in modern organic synthesis. Both functional group reductions and reductive couplings are commonly performed with Kagan's reagent and the appropriate selection of additives and co-solvents can lead to extraordinary levels of selectivity.Recent discoveries have showcased the great potential of SmI2 for the mild and selective ET reduction of functional groups which otherwise need harsh conditions to be transformed. For example, carboxylic acids, esters,4 amides5 and nitriles6 are exciting new substrates for SmI2-mediated processes. Crucially, SmI2 not only provides new ways to perform functional group reductions, but can also unlock new reactivity in many different substrates leading to, for example, new C–C bond-forming processes that deliver complex molecular architectures.Due to the high versatility of SmI2, it is widely used in key steps during the synthesis of complex organic molecules, often providing outstanding outcomes that cannot be paralleled by other reagents. Therefore, SmI2 has found application not only in the synthesis of natural products and pharmaceuticals, but also in other fi